Experiences with the shikimate-pathway enzymes as targets for rational drug design. (1st June 2003)
- Record Type:
- Journal Article
- Title:
- Experiences with the shikimate-pathway enzymes as targets for rational drug design. (1st June 2003)
- Main Title:
- Experiences with the shikimate-pathway enzymes as targets for rational drug design
- Authors:
- Coggins, J.R.
Abell, C.
Evans, L.B.
Frederickson, M.
Robinson, D.A.
Roszak, A.W.
Lapthorn, A.P. - Abstract:
- Abstract : The background and current context of work on the shikimate-pathway enzymes as potential targets for anti-bacterial, anti-fungal and anti-parasitic drugs is reviewed. Recent work on the third enzyme of the pathway, dehydroquinase, which occurs in two structurally and mechanistically distinct forms, is used to illustrate the present state of studies into rational drug design.
- Is Part Of:
- Biochemical Society transactions. Volume 31:Number 3(2003)
- Journal:
- Biochemical Society transactions
- Issue:
- Volume 31:Number 3(2003)
- Issue Display:
- Volume 31, Issue 3 (2003)
- Year:
- 2003
- Volume:
- 31
- Issue:
- 3
- Issue Sort Value:
- 2003-0031-0003-0000
- Page Start:
- 548
- Page End:
- 552
- Publication Date:
- 2003-06-01
- Subjects:
- dehydroquinone -- dehydroquinone inhibitor -- 5-enolpyruvylshikimate-3-phosphate synthase (EPSP synthase) -- 6-fluoroshikimate -- rational drug design -- shikimate pathway
Biochemistry -- Congresses
572 - Journal URLs:
- https://portlandpress.com/biochemsoctrans ↗
- DOI:
- 10.1042/bst0310548 ↗
- Languages:
- English
- ISSNs:
- 0300-5127
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library HMNTS - ELD Digital store
- Ingest File:
- 16091.xml