Enhanced production of dolichol, but not dolichyl phosphate, in the earliest stages of rat liver regeneration. Issue 4 (April 1986)

• Record Type: Journal Article
• Authors: Marino, M.; Bruscalupi, G.; Spagnuolo, S.; Leoni, S.; Mangiantini, M. T.; Trentalance, A.; Hemming, F. W.
• Is Part Of: Bioscience reports. Volume 6:Issue 4(1986)
• Page Start: 409
• Page End: 413
• Publication Date: 1986-04
• Subjects: 3-hydroxy-3-methylglutaryl-coenzyme A reductase -- mevalonate -- dolichol -- dolichylphosphate -- ubiquinone -- regeneration (rat liver); Molecular biology -- Periodicals; Cytology -- Periodicals; 572.8
• DOI: 10.1007/BF01116429
• Languages: English
• ISSNs: 0144-8463

Abstract

Abstract : The regenerating liver presents a changed ability to use mevalonate 16 hr after partial hepatectomy. The dolichol content and its synthesis from mevalonate is increased, while no variation of dolichyl-P and ubiquinone parameters are detectable. The greater amount ofmevalonate utilized to form dolichol, but not dolichyl-P, in this proliferating system, raises some questions about the physiological significance of these isoprenoid compounds and about their biosynthetic sequence.