Bicyclic lactones from the octocoral Dendronephthya mucronata. Issue 7 (3rd April 2021)

• Record Type: Journal Article
• Authors: Ngoc, Ninh Thi; Hanh, Tran Thi Hong; Nguyen, Hai Dang; Quang, Tran Hong; Cuong, Nguyen Xuan; Nam, Nguyen Hoai; Thung, Do Cong; Ngai, Nguyen Dang; Kiem, Phan Van; Minh, Chau Van
• Is Part Of: Natural product research. Volume 35:Issue 7(2021)
• Page Start: 1134
• Page End: 1138
• Publication Date: 2021-04-03
• Subjects: Dendronephthya mucronata -- Nephtheidae -- bicyclic lactone -- cytotoxic activity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2019.1643860
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: The MeOH extract of the Vietnamese octocoral Dendronephthya mucronata afforded four bicyclic lactones (1 –4 ), including three new compounds namely dendronephthyones A–C (1 –3 ), after subjecting it on various chromatographic separations. The structures of the isolated compounds were established by spectroscopic experiments including 1D, 2D NMR, CD and HR-QTOF-MS. In addition, compounds 1 –4 were found to exhibit selective cytotoxicity against the HeLa human cancer cell line with IC50 values of 32.48 ± 2.15, 30.12 ± 1.86, 35.14 ± 1.57 and 14.45 ± 1.34 μM, respectively. Abstract :