Glycogenolytic effect of pancreastatin in the rat. Issue 1 (February 1990)

• Record Type: Journal Article
• Authors: Sanchez, Victor; Calvo, Juan R.; Goberna, Raimundo
• Is Part Of: Bioscience reports. Volume 10:Issue 1(1990)
• Page Start: 87
• Page End: 91
• Publication Date: 1990-02
• Subjects: glycogen -- pancreastatin; Molecular biology -- Periodicals; Cytology -- Periodicals; 572.8
• DOI: 10.1007/BF01116856
• Languages: English
• ISSNs: 0144-8463

Abstract

Abstract : Pancreastatin is a novel 49-amino acid peptide with a C-terminal glycine amide. The peptide was isolated from porcine pancreatic extracts and shows a structural similarity to chromogranin A. The effect of synthetic porcine pancreastatin on blood glucose levels and hepatic glycogen content was investigated in rats in vivo . Pancreastatin (300 pmol/kg) produced a time-dependent decrease in glycogen content of liver and a slight hyperglycemia. Basal plasma insulin and glucagon levels were not modified by pancreastatin. We suggest that pancreastatin could play a biological role in the glucose metabolism through a glycogenolytic effect.