Interaction of thymic peptide thymosin α1 with vasoactive intestinal peptide (VIP) receptors. Issue 8 (August 1986)

• Record Type: Journal Article
• Authors: Calvo, J. R.; Goberna, R.; Guerrero, J. M.
• Is Part Of: Bioscience reports. Volume 6:Issue 8(1986)
• Page Start: 727
• Page End: 733
• Publication Date: 1986-08
• Subjects: Thymosin -- vasoactive intestinal peptide; Molecular biology -- Periodicals; Cytology -- Periodicals; 572.8
• DOI: 10.1007/BF01116540
• Languages: English
• ISSNs: 0144-8463

Abstract

Abstract : Thymic peptide thymosin α1 (10 −9 to 3 × 1010 −7 M) is shown to inhibit the specific binding of [ 125 I]VIP to rat blood mononuclear cells and liver plasma membranes. Thymosin α1 was 160 and 6250 times less potent that VIP at inhibiting [ 125 I]VIP binding to blood mononuclear cells and liver plasma membranes, respectively. Thymosin α1 (10 −10 to 1010 −7 M) was weak in stimulating adenylate cyclase activity. Its efficacy is about 25 % and 27 % that of native VIP in blood mononuclear cells and liver plasma membranes, respectively. Thymosin α1 may behave as a partial VIP agonist in rat.