The zDHHC family of S-acyltransferases. (7th April 2015)

• Record Type: Journal Article
• Authors: Lemonidis, Kimon; Werno, Martin W.; Greaves, Jennifer; Diez-Ardanuy, Cinta; Sanchez-Perez, Maria C.; Salaun, Christine; Thomson, David M.; Chamberlain, Luke H.
• Is Part Of: Biochemical Society transactions. Volume 43:Number 2(2015)
• Page Start: 217
• Page End: 221
• Publication Date: 2015-04-07
• Subjects: palmitoylation zDHHC enzymes -- S-acylation -- thioesterases; Biochemistry -- Congresses; 572
• DOI: 10.1042/BST20140270
• Languages: English
• ISSNs: 0300-5127

Abstract

Abstract : The discovery of the zDHHC family of S-acyltransferase enzymes has been one of the major breakthroughs in the S-acylation field. Now, more than a decade since their discovery, major questions centre on profiling the substrates of individual zDHHC enzymes (there are 24 ZDHHC genes and several hundred S-acylated proteins), defining the mechanisms of enzyme-substrate specificity and unravelling the importance of this enzyme family for cellular physiology and pathology.