Additional signals from VPAC/PAC family receptors. (August 2002)

• Record Type: Journal Article
• Authors: McCulloch, D. A.; MacKenzie, C. J.; Johnson, M. S.; Robertson, D. N.; Holland, P. J.; Ronaldson, E.; Lutz, E. M.; Mitchell, R.
• Is Part Of: Biochemical Society transactions. Volume 30:Number 4(2002)
• Page Start: 441
• Page End: 446
• Publication Date: 2002-08
• Subjects: ADP-ribosylation factor -- G-protein -- phospholipases C/D -- pituitary adenylate cyclase-activating polypeptide (PACAP) -- vasoactive intestinal polypeptide (VIP); ARF, ADP-ribosylation factor -- ERK, extracellular-signal-regulated kinase -- GPCR, G-protein-coupled receptor -- GRK, GPCR kinase -- PACAP, pituitary adenylate cyclase-activating polypeptide -- PKA, protein kinase A -- PLC, phospholipase C -- PLD, phospholipase D -- PTx, pertussis toxin -- VIP, vasoactive intestinal polypeptide; Biochemistry -- Congresses; 572
• DOI: 10.1042/bst0300441
• Languages: English
• ISSNs: 0300-5127

Abstract

Abstract : The receptors for the neuropeptides vasoactive intestinal polypeptide and pituitary adenylate cyclase-activating polypeptide are strong activators of adenylate cyclase, but recent evidence suggests that they can elicit a number of additional intracellular signals. Some of these are likely to be downstream of the conventional adenylate cyclase pathway, but it is now clear that others reflect novel primary coupling events of the receptors.