AAA+ proteins: diversity in function, similarity in structure. (22nd January 2008)

• Record Type: Journal Article
• Authors: Snider, Jamie; Houry, Walid A.
• Is Part Of: Biochemical Society transactions. Volume 36:Number 1(2008)
• Page Start: 72
• Page End: 77
• Publication Date: 2008-01-22
• Subjects: ATPase associated with various cellular activities (AAA+) -- P-loop NTPase -- remodelling -- Walker A motif -- Walker B motif; Biochemistry -- Congresses; 572
• DOI: 10.1042/BST0360072
• Languages: English
• ISSNs: 0300-5127

Abstract

Abstract : The AAA+ (ATPases associated with various cellular activities) superfamily of proteins represents a distinct lineage of the larger class of P-loop NTPases. Members of this superfamily use the power of nucleotide binding and hydrolysis to direct molecular remodelling events. All AAA+ proteins share a common core architecture, which, through various sequence and structural modifications, has been adapted for use in a remarkably diverse range of functions. The following mini-review provides a concise description of the major structural elements common to all AAA+ proteins in the context of their mechanistic roles. In addition, the evolutionary and functional diversity of this superfamily is described on the basis of recent classification studies.