"Protenuria in SLE: Is it always lupus?". (April 2021)

• Record Type: Journal Article
• Authors: Celia, Alessandra Ida; Priori, Roberta; Cerbelli, Bruna; Diomedi-Camassei, Francesca; Leuzzi, Vincenzo; Scrivo, Rossana; Alessandri, Cristiano; d'Amati, Giulia; Conti, Fabrizio
• Is Part Of: Lupus. Volume 30:Number 4(2021)
• Page Start: 664
• Page End: 668
• Publication Date: 2021-04
• Subjects: Systemic lupus erythematosus -- Fabry disease -- hydroxychloroquine -- proteinuria -- renal biopsy; Systemic lupus erythematosus -- Periodicals; 616.772005
• DOI: 10.1177/0961203320983458
• Languages: English
• ISSNs: 0961-2033

Abstract

Proteinuria is one of the most typical manifestations of kidney involvement in Systemic Lupus Erythematosus (SLE). We report the case of a 23-year-old woman with a 6-year-long history of SLE presenting with proteinuria after a three-year remission on hydroxychloroquine. Kidney histological examination showed alterations inconsistent with lupus nephritis and suggestive of hydroxychloroquine toxicity or Fabry disease. The latter was confirmed by genetic assay.