D-Glucose uptake and clearance in the tauopathy Alzheimer's disease mouse brain detected by on-resonance variable delay multiple pulse MRI. Issue 5 (May 2021)

• Record Type: Journal Article
• Authors: Chen, Lin; Wei, Zhiliang; Chan, Kannie WY; Li, Yuguo; Suchal, Kapil; Bi, Sheng; Huang, Jianpan; Xu, Xiang; Wong, Philip C; Lu, Hanzhang; van Zijl, Peter CM; Li, Tong; Xu, Jiadi
• Is Part Of: Journal of cerebral blood flow & metabolism. Volume 41:Issue 5(2021)
• Page Start: 1013
• Page End: 1025
• Publication Date: 2021-05
• Subjects: Glucose uptake -- Alzheimer's diseases -- on-resonance variable delay multiple pulse -- dynamic glucose enhanced -- chemical exchange saturation transfer -- tau pathology; Cerebral circulation -- Periodicals; Brain -- Metabolism -- Periodicals; Brain -- Blood-vessels -- Periodicals; Cerebrovascular disease -- Periodicals; 612.824
• DOI: 10.1177/0271678X20941264
• Languages: English
• ISSNs: 0271-678X

Abstract

In this study, we applied on-resonance variable delay multiple pulse (onVDMP) MRI to study D-glucose uptake in a mouse model of Alzheimer's disease (AD) tauopathy and demonstrated its feasibility in discriminating AD mice from wild-type mice. The D-glucose uptake in the cortex of AD mice (1.70 ± 1.33%) was significantly reduced compared to that of wild-type mice (5.42 ± 0.70%, p = 0.0051). Also, a slower D-glucose uptake rate was found in the cerebrospinal fluid (CSF) of AD mice (0.08 ± 0.01 min −1 ) compared to their wild-type counterpart (0.56 ± 0.1 min −1, p < 0.001), which suggests the presence of an impaired glucose transporter on both blood–brain and blood–CSF barriers of these AD mice. Clearance of D-glucose was observed in the CSF of wild-type mice but not AD mice, which suggests dysfunction of the glymphatic system in the AD mice. The results in this study indicate that onVDMP MRI could be a cost-effective and widely available method for simultaneously evaluating glucose transporter and glymphatic function of AD. This study also suggests that tau protein affects the D-glucose uptake and glymphatic impairment in AD at a time point preceding neurofibrillary tangle pathology.