Cerebral Hemangioblastoma Without Von Hippel-Lindau Syndrome: A Report of 6 Cases. (April 2021)

• Record Type: Journal Article
• Authors: Qu, Limei; Lv, Chuanqi; Ji, Tiefeng; Wang, Yinping; Yu, Jinlu
• Is Part Of: International journal of surgical pathology. Volume 29:Number 2(2021)
• Page Start: 129
• Page End: 134
• Publication Date: 2021-04
• Subjects: hemangioblastoma -- cerebrum -- cerebellum -- clinicopathology -- radiology; Pathology, Surgical -- Periodicals; 617.07
• DOI: 10.1177/1066896920933998
• Languages: English
• ISSNs: 1066-8969

Abstract

Background . Hemangioblastoma occurs mainly in the cerebellum and rarely in the cerebrum. Objective . The present study aimed to analyze the clinical manifestations and radiological and pathological features of cerebral hemangioblastoma, and to improve the recognition of this tumor and avoid misdiagnosis. Methods . The characteristics of 6 patients with cerebral hemangioblastoma were analyzed, and a retrospective review of cerebral hemangioblastoma reported in the literature was performed. Results . All 6 patients were female, aged from 22 to 70 years (55 years on average), and all cases were wild-type sporadic, in which 4 cases occurred in the frontal lobe and 2 cases occurred in the parietal lobe. Imaging revealed a solid tumor in 4 cases, a cystic tumor in 1 case, and a mixed tumor in 1 case. Microscopically, the morphology and immunophenotype of tumor cells were not different from those of classical hemangioblastoma. All 6 patients survived tumor free during the follow-up period. Conclusions . Cerebral hemangioblastoma often simulates the imaging characteristics of meningioma or glioma. Enough attention should be paid to differential diagnosis before the operation, and exact diagnosis relies on the pathological examination.