Sesquiterpenoids and meroterpenoids from a mangrove derived fungus Diaporthe sp. SCSIO 41011. Issue 2 (17th January 2021)

• Record Type: Journal Article
• Authors: Luo, Xiao-Wei; Chen, Chun-Mei; Li, Kun-Long; Lin, Xiu-Ping; Gao, Cheng-Hai; Zhou, Xue-Feng; Liu, Yong-Hong
• Is Part Of: Natural product research. Volume 35:Issue 2(2021)
• Page Start: 282
• Page End: 288
• Publication Date: 2021-01-17
• Subjects: Sesquiterpenoids -- chrodrimanins -- marine fungi -- Diaporthe sp; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2019.1627355
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: One new sesquiterpenoid, 1-methoxypestabacillin B (1 ), along with one known sesquiterpenoid (2 ) and six known chrodrimanin-type meroterpenoids (3 ‒8 ) were obtained from the solid cultures of a mangrove endophytic fungus Diaporthe sp. SCSIO 41011. Their structures including the absolute configuration at C-6 of compound 1, were determined by extensive spectroscopic analyses and ECD calculations. Meanwhile, the X-ray crystal structures and absolute configurations of two previously reported chrodrimanins E (3 ) and H (6 ), are described for the first time. All the compounds were examined for HIV latency-reversal and anti-influenza A virus activities. Graphical Abstract: