Chelerythrine as a fluorescent light-up ligand for an i-motif DNA structure. (11th December 2020)

• Record Type: Journal Article
• Authors: Chen, Hongbo; Sun, Hongxia; Zhang, Wende; Zhang, Qin; Ma, Jun; Li, Qian; Guo, Xiaomeng; Xu, Kanyan; Tang, Yalin
• Is Part Of: New journal of chemistry. Volume 45:Number 1(2021)
• Page Start: 28
• Page End: 31
• Publication Date: 2020-12-11
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/d0nj04863a
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : A fluorescent light-up ligand for an i-motif structure has been reported in this study. Abstract : A fluorescent light-up ligand for an i-motif structure has been reported in this study. Chelerythrine (CHE) could bind to i-motif and show a significant increase in the fluorescence intensity, while exhibiting weak response towards single-stranded (ssDNA), double-stranded (dsDNA), and G-quadruplexes. This feature makes CHE advantageous in the label-free fluorescence sensing systems.