From the gut to the heart: L. plantarum and inulin administration as a novel approach to control cardiac apoptosis via 5-HT2B and TrkB receptors in diabetes. Issue 1 (January 2021)

• Record Type: Journal Article
• Authors: Sefidgari-Abrasi, Safa; Roshangar, Leila; Karimi, Pouran; Morshedi, Mohammad; Rahimiyan-Heravan, Marziyeh; Saghafi-Asl, Maryam
• Is Part Of: Clinical nutrition. Volume 40:Issue 1(2021)
• Page Start: 190
• Page End: 201
• Publication Date: 2021-01
• Subjects: Apoptosis -- Brain-derived neurotrophic factor -- Inulin -- Lactobacillus plantarum -- Serotonin -- Type 2 diabetes mellitus; 5-HT 5-Hydroxytryptamine -- 5-HT2B 5-Hydroxytryptamine 2B -- BAX Bcl-2-associated X protein -- Bcl-2 B-cell lymphoma 2 -- BDNF brain-derived neurotrophic factor -- HFD high-fat diet -- IGF1R insulin-like growth factor 1 receptor -- L. plantarum Lactobacillus plantarum -- PI3K/Akt phosphoinositide 3-kinase/protein kinase B -- STZ streptozotocin -- TrkB tropomyosin receptor kinase B; Critically ill -- Nutrition -- Periodicals; Diet therapy -- Periodicals; Parenteral feeding -- Periodicals; Enteral feeding -- Periodicals; Enteral Nutrition -- Periodicals; Parenteral Nutrition -- Periodicals; Metabolism -- Periodicals; Diétothérapie -- Périodiques; Alimentation parentérale -- Périodiques; Alimentation entérale -- Périodiques; Nutrition -- Périodiques; Diet therapy; Enteral feeding; Nutrition; Parenteral feeding; Electronic journals; Periodicals; Electronic journals; 615.854
• DOI: 10.1016/j.clnu.2020.05.004
• Languages: English
• ISSNs: 0261-5614

Abstract

Summary: Background & aims: Type 2 diabetes mellitus, as a metabolic disorder, can lead to diabetic cardiomyopathy, identified by cardiomyocyte apoptosis and myocardial fibrosis. Brain-derived neurotrophic factor (BDNF) and serotonin are two neurotransmitters that can control cardiomyocyte apoptosis and myocardial fibrosis through their cardiac receptors. In the present study, we investigated the impacts of L . plantarum and inulin supplementation on the inhibition of cardiac apoptosis and fibrosis by modulating intestinal, serum, and cardiac levels of serotonin and BDNF as well as their cardiac receptors. Methods: Diabetes was induced by a high-fat diet and streptozotocin in male Wistar rats. Rats were divided into six groups and were supplemented with L . plantarum, inulin or their combination for 8 weeks. Finally, the rats were killed and levels of intestinal, serum, and cardiac parameters were evaluated. Results: Concurrent administration of L . plantarum and inulin caused a significant rise in the expression of cardiac serotonin and BDNF receptors (P < 0.001) as well as a significant fall in cardiac interstitial and perivascular fibrosis (P < 0.001, both) and apoptosis (P = 0.01). Moreover, there was a strong correlation of cardiac 5-Hydroxytryptamine 2B (5-HT2B) and tropomyosin receptor kinase B (TrkB) receptors with interstitial/perivascular fibrosis and apoptosis (P < 0.001, both). Conclusions/interpretation: Results revealed beneficial effects of L . plantarum, inulin or their combination on intestinal, serum, and cardiac serotonin and BDNF accompanied by higher expression of their cardiac receptors and lower levels of cardiac apoptotic and fibrotic markers. It seems that L . plantarum and inulin supplementation could be considered as a novel adjunct therapy to reduce cardiac complications of type 2 diabetes mellitus.