Antibody-guided structure-based vaccines. (August 2020)

• Record Type: Journal Article
• Authors: Kwong, Peter D.; DeKosky, Brandon J.; Ulmer, Jeffrey B.
• Is Part Of: Seminars in immunology. Volume 50(2020)
• Publication Date: 2020-08
• Subjects: Antibody -- Atomic-level design -- Immune monitoring -- mRNA delivery -- Next-generation sequencing (NGS) -- Nucleic acid-based vaccines -- Vaccine R&D; Immunology -- Periodicals; Allergy and Immunology -- Periodicals; Immunity -- Periodicals; Immunologie -- Périodiques; Electronic journals; 616.079
• DOI: 10.1016/j.smim.2020.101428
• Languages: English
• ISSNs: 1044-5323

Abstract

Highlights: Reviews antibody-guided approaches to streamline vaccine discovery and development. Delineates principles underlying antibody-guided structure-based vaccines. Summarizes recently developed tools that are accelerating antibody-guided vaccines. Outlines challenges and opportunities to translate discoveries into vaccines. Provides examples of rapid response to emerging infectious diseases (e.g. COVID-19). Abstract: The vaccine field is pursuing diverse approaches to translate the molecular insights from analyses of effective antibodies and their targeted epitopes into immunogens capable of eliciting protective immune responses. Here we review current antibody-guided strategies including conformation-based, epitope-based, and lineage-based vaccine approaches, which are yielding promising vaccine candidates now being evaluated in clinical trials. We summarize directions being employed by the field, including the use of sequencing technologies to monitor and track developing immune responses for understanding and improving antibody-based immunity. We review opportunities and challenges to transform powerful new discoveries into safe and effective vaccines, which are encapsulated by vaccine efforts against a variety of pathogens including HIV-1, influenza A virus, malaria parasites, respiratory syncytial virus, and SARS-CoV-2. Overall, this review summarizes the extensive progress that has been made to realize antibody-guided structure-based vaccines, the considerable challenges faced, and the opportunities afforded by recently developed molecular approaches to vaccine development.