An alternative synthesis for iloprost via a key bicyclic aldehyde intermediate. (5th January 2021) - Chen, Yinbo
Graphical abstract: Highlights: An alternative synthesis for iloprost is presented. The shortest synthetic approach for iloprost was achieved in 14 steps. The synthesis started from commercially available (−)-Corey lactone diol. Abstract: An alternative synthesis for iloprost has been accomplished in 14 steps via a convergent synthesis starting from commercially available (−)-Corey lactone diol. The syntheses employ a new and key chiral bicyclic aldehyde (4 ) intermediate, which is primed for attachment of the required α-side chain and ω-side chain.