The sweet side of dark chocolate for chronic kidney disease patients. Issue 1 (January 2021)

• Record Type: Journal Article
• Authors: Fanton, Susane; Cardozo, Ludmila F.M.F.; Combet, Emilie; Shiels, Paul G.; Stenvinkel, Peter; Vieira, Itamar Oliveira; Narciso, Humberto Rebello; Schmitz, Jerry; Mafra, Denise
• Is Part Of: Clinical nutrition. Volume 40:Issue 1(2021)
• Page Start: 15
• Page End: 26
• Publication Date: 2021-01
• Subjects: Chronic kidney disease -- Dark chocolate -- Oxidative stress -- Inflammation -- Gut microbiota; AP-1 Activating protein 1 -- CKD Chronic Kidney Disease -- DC dark chocolate -- G6PD Glucose-6-phosphate dehydrogenase -- HO-1 Heme oxygenase 1 -- HD Hemodialysis -- MAPKs Mitogen- activated protein kinases -- NQO1 NAD(P) H:quinone oxidoreductase1 -- NO Nitric oxide -- Nrf2 Nuclear factor erythroid factor 2-related -- NF-kB Nuclear factor Kappa B -- PI3K Phosphatidylinositol 3-kinase; Critically ill -- Nutrition -- Periodicals; Diet therapy -- Periodicals; Parenteral feeding -- Periodicals; Enteral feeding -- Periodicals; Enteral Nutrition -- Periodicals; Parenteral Nutrition -- Periodicals; Metabolism -- Periodicals; Diétothérapie -- Périodiques; Alimentation parentérale -- Périodiques; Alimentation entérale -- Périodiques; Nutrition -- Périodiques; Diet therapy; Enteral feeding; Nutrition; Parenteral feeding; Electronic journals; Periodicals; Electronic journals; 615.854
• DOI: 10.1016/j.clnu.2020.06.039
• Languages: English
• ISSNs: 0261-5614

Abstract

Summary: Chocolate is a widely appreciated foodstuff with historical appreciation as a food from the gods. In addition to its highly palatable taste, it is a rich source of (poly)phenolics, which have several proposed salutogenic effects, including neuroprotective anti-inflammatory, anti-oxidant and cardioprotective capabilities. Despite the known benefits of this ancient foodstuff, there is a paucity of information on the effects of chocolate in the context of chronic kidney disease (CKD). This review focusses on the potential salutogenic contribution of chocolate intake, to mitigate inflammatory and oxidative burden in CKD, its potential, for cardiovascular protection and on the maintenance of diversity in gut microbiota, as well as clinical perspectives, on regular chocolate intake by CKD patients.