352 QUALITY OF LIFE OF PATIENTS UNDERGOING SURGERY FOR ESOPHAGEAL AND GASTROESOPHAGEAL JUNCTION CANCER. (14th September 2020)

• Record Type: Journal Article
• Authors: Lidoriki, I; Schizas, D; Mylonas, K; Alexandrou, A; Karavokyros, I; Liakakos, T
• Is Part Of: Diseases of the esophagus. Volume 33(2020)Supplement 1
• Publication Date: 2020-09-14
• Subjects: Esophagus -- Diseases -- Periodicals; 616.32
• DOI: 10.1093/dote/doaa087.79
• Languages: English
• ISSNs: 1120-8694

Abstract

Abstract: : The assessment of patients' quality of life is increasingly gaining ground as an effective approach to evaluate treatment efficacy and patients satisfaction in the clinical setting. The aim of this study was to investigate the association between patients' preoperative nutritional status and quality of life, as well as to examine quality of life changes at six months postoperatively in patients undergoing surgery for esophageal and gastroesophageal junction cancer. Methods: The study sample consisted of 93 patients with esophageal (n = 14) and gastroesophageal junction cancer (n = 79) who were admitted for surgery in the xxxxx between September 2015 and July 2019. Out of them, 77 patients underwent esophagectomy while 16 patients underwent total gastrectomy. The preoperative evaluation of patients' nutritional status was based on Patient Generated Subjective Global Assessment (PG-SGA) and Skeletal Muscle Index (SMI) derived from analysis of CT scans, while the assessment of patients' quality of life (QoL) was based on EORTC QLQ-C30 questionnaire (version 3.0). Patients' follow-up was done six months postoperatively. Results: Forty three patients (46.2%) were diagnosed with sarcopenia. The prevalence of malnutrition was 64%. Sarcopenic patients scored lower on Global Health (59.94 ± 19.21 vs 65.68 ± 20.08, p = 0.050), Physical Functioning (77.63 ± 23.08 vs 86.58 ± 15.26, p = 0.003) and higher on Fatigue (35.80 ± 25.19 vs 25.73 ± 22.31, p = 0.008) compared with non-sarcopenic patients. Μalnourished patients exhibited more impaired QoL, except Emotional Functioning, compared to well-nourished patients. Physical Functioning (79.9 ± 18.3 vs 88.2 ± 12.9, p = 0.004) and Social Functioning (67.7 ± 22.6 vs 83.1 ± 20.8, p < 0.001) were lower, while Pain (19.9 ± 19.0 vs 13.9 ± 17.9, p = 0.050), Diarrhea (19.4 ± 22.2 vs 9.7 ± 19.5, p = 0, 011) and Financial Difficulties (21.0 ± 21.1 vs 12.9 ± 23.7, p = 0.031) were higher at six months postoperatively compared to the preoperative levels. Conclusion: Sarcopenia and malnutrition affected several parameters of health related QoL in patients undergoing surgery for esophageal and gastroesophageal junction cancer. Moreover, various components of the QoL significantly declined at six months postoperatively. These results indicate that preoperative nutritional assessment is necessary in order to prevent further deterioration of nutritional and functional status, which, in turn may worsen patients' QoL.