Tetra-arylborate lipophilic anions as targeting groups. Issue 25 (26th February 2021)

• Record Type: Journal Article
• Authors: Gaddale Devanna, Kishore K.; Gawel, Justyna M.; Prime, Tracy A.; Cvetko, Filip; Benincá, Cristiane; Caldwell, Stuart T.; Negoda, Alexander; Harrison, Andrew; James, Andrew M.; Pavlov, Evgeny V.; Murphy, Michael P.; Hartley, Richard C.
• Is Part Of: Chemical communications. Volume 57:Issue 25(2021)
• Page Start: 3147
• Page End: 3150
• Publication Date: 2021-02-26
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d0cc07924c
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : TPB lipophilic anions deliver cargoes to lysosomes and are excluded from mitochondria. Abstract : Tetraphenylborate (TPB) anions traverse membranes but are excluded from mitochondria by the membrane potential (Δ ψ ). TPB-conjugates also distributed across membranes in response to Δ ψ, but surprisingly, they rapidly entered cells. They accumulated within lysosomes following endocystosis. This pH-independent targeting of lysosomes makes possible new classes of probe and bioactive molecules.