Identification of an Emergent Pathogen, Bartonella vinsonii, Using Next-Generation Sequencing in a Patient With Culture-Negative Endocarditis. (24th February 2020)

• Record Type: Journal Article
• Authors: Downey, Rachel D; Russo, Susan M; Hauger, Sarmistha B; Murphey, Donald K; Marx, Grace; Huynh, Thanhthao; Denison, Amy M; Quirt, Rachel; Bailey, Ann; Fernandez, Marisol
• Is Part Of: Journal of the Pediatric Infectious Diseases Society. Volume 10:Number 2(2021)
• Page Start: 213
• Page End: 216
• Publication Date: 2020-02-24
• Subjects: Bartonella vinsonii -- diagnostics -- endocarditis -- glomerulonephritis -- next-generation sequencing; Communicable diseases in children -- Periodicals; Children -- Diseases -- Periodicals; 618.929
• DOI: 10.1093/jpids/piaa014
• Languages: English
• ISSNs: 2048-7193

Abstract

Abstract: Diagnosis and treatment of culture negative endocarditis remains a challenge. This report describes a rare cause of endocarditis in humans, Bartonella vinsonii, identified through next generation sequencing of plasma microbial cell-free DNA with confirmation of cardiac valve tissue infection through immunohistochemical staining and polymerase chain reaction.