Methods of synthesis, characterization and biomedical applications of biodegradable poly(ester amide)s- A review. (November 2020)

• Record Type: Journal Article
• Authors: Ranganathan, Palraj; Chen, Chin-Wen; Rwei, Syang-Peng; Lee, Yi-Huan; Ramaraj, Sayee Kannan
• Is Part Of: Polymer degradation and stability. Volume 181(2020)
• Publication Date: 2020-11
• Subjects: Poly(ester amide)s -- Biodegradable materials -- Synthesis methods -- Polydepsipeptides -- Biomedical applications; EDO 1, 2-ethanediol -- PDO 1, 3-propanediol -- DAG 1, 4:3, 6-dianhydro-D-glucitol -- DAM 1, 4:3, 6-dianhydromannitol -- DAS 1, 4:3, 6-dianhydrosorbitol -- PDO 1, 4-butanediol -- HDO 1, 6-hexanediol -- ODO 1, 8-octanediol -- BD 2-butane-1, 4-diol -- 4-amino-TEMPO 4-amino-2, 2, 6, 6-tetramethylpiperidine oxide -- HBA 4-hydroxybenzoic acid -- CH3COOH acetic acid -- AA adipic acid -- AC adipoyl chloride -- AZA azelaic acid -- AZC azeloyl chloride -- HES bis(2-hydroxyethyl)dislufide -- CCl4 carbon tetrachloride -- CHCl3 chloroform -- CA citric acid -- PLA. D2-LLA15-D2 poly(L-lactide) -- D-Glu- δ-Lac D-glucano-δ-lactone -- CHCl2COOH dichloroacetic acid -- DCM dichloromethane -- CHCl2 dichloromethaneide -- DEG diethylene glycol -- DMAc dimethylacetamide -- DMF dimethylformamide -- DMSO dimethylsulfoxide -- DL-AG DL-2-allylglycine -- DL-LA DL-lactic acid -- DL-Nor DL-norleucine -- DL-Phe DL-phenylalanine -- DDA dodecanedioic acid -- DDC dodecanoyl chloride -- FA fumaric acid -- FC fumaryl chloride -- GC glutaryl chloride -- Gly glycine -- GA glycolic acid -- GGly glycylglycine -- HCASMCs human coronary artery smooth muscle cells -- HEK293 cells human embryonic kidney 293 cells -- SMMC-7721 human hepatocellular carcinoma cell line -- HBr hydrogen bromide -- IPC isophthaloyl dichloride -- L-Ala L-alanine -- L-Arg-HCl L-arginine hydrochloride -- L-Arg L-arginine -- L-Asp L-aspartic acid -- L-Cys L-cysteine -- L-GA L-glutamic acid -- L-His L-histidine -- L-Iso L-isoleucine -- L-LA L-lactic acid -- L-Leu L-leucine -- L-Lys L-lysine -- L-Phe L-phenylalanine -- L-Pro L-proline -- L-Ser L-serine -- L-Val L-valine -- MDCK Madin-Darby canine kidney cells -- MA maleic acid -- Tm melting temperature -- Met methionine -- MEMMC mouse embryonic mesenchymal multipotent cells -- 10T1/2 mouse embryonic multipotent mesenchymal progenitor cell line -- H-Lys(Z)-OH Nɛ-Z-L-lysine -- NMP N-methyl-2-pyrrolidine -- Mn number-average molecular weight -- PCX paclitaxel -- PDP-b-PLLA PDP-b-poly(L-lactic acid) -- PLGA poly(lactic-co-glycolic acid) -- PA pimelic acid -- PC pimelolyl chloride -- PCA pipecolinic acid -- PLHP poly(D, L-lactide-co-hydroxy-L-proline) -- PEG poly(ethylene glycol) -- PCL-diol poly(ɛ-caprolactone) diol -- PCL poly(ɛ-caprolactone) -- pK-pLL-pEG poly(L-lysine-)-b-poly(L-lactide)-b-poly(L-lysine): poly(L-lysine-g-(lactide-b-ethylene glycol)) -- PDP poly[(L-alanyl)n-g-ethyl-L-glutamyl-L-lactyl]-poly[(Ala)n-Glu(OEt)-Lac] -- p-toluene sulfonic acid p-TSA -- VSMCs rat vascular smooth muscle cells -- SA sebacic acic -- SC sebacoyl chloride -- Na2CO3 sodium carbonate -- S-Tyr S-tyrosine -- SUA suberic acid -- SBC suberyl chloride -- SCA succinic acid -- SC succinyl chloride -- TPA terephthalic acid -- TPC terephthaloyl dichloride -- Ti(OBu)4 tetrabutoxytitanium -- TTEG tetraethylene glycol -- Tg Tm, glass transition temperature -- Et3N triethylamie -- TEG triethylene glycol -- TFE trifluoroethanol -- VA vanillic acid -- [ƞ] viscosity -- Mv viscosity-average molecular weight -- WEFFM waveguide evanescent field fluorescence microscopy -- α-CT α-chymotrypsin -- β-AlaCOOEt-HCl β-alanine ethyl ester hydrochloride -- β-Ala β-alanine -- CL ε-caprolactone; Polymers -- Deterioration -- Periodicals; Stabilizing agents -- Periodicals; Polymères -- Dégradation -- Périodiques; Stabilisants -- Périodiques; 668.9
• DOI: 10.1016/j.polymdegradstab.2020.109323
• Languages: English
• ISSNs: 0141-3910

Abstract

Highlights: We are critically reviewed the synthesis and characterization of biodegradable PEAs. Various synthesis methods used to prepare PEAs have been covered. The applications of biodegradable PEAs are intensively studied. Specifics studies on biomedical applications of α-amino acids based PEAs are described. Abstract: Poly(ester amide)s (PEAs) have developed in current years as a vital class of synthetic biodegradable materials with specialty applications in various fields. These PEAs provide both amide and ester groups in their chemical structure, and they combine the finest mechanical and thermal properties of polyamides with the most fabulous biodegradable properties of polyesters. PEAs can be manufactured via various monomers and adopting different synthesis procedures, leading to PEAs with ordered, blocky, and random structures. Mainly, PEAs comprising α-amino acids (α-AAs) have grown as essential biomaterials in the biomedical fields (e.g., drug delivery, tissue engineering, hydrogels, and smart materials). The existence of α -AAs offers to more reliable cell-polymer interactions, permits the establishment of carboxyl, hydroxyl, and amine pendant reaction groups, and improves the overall PEAs biodegradability. In this paper, a comprehensive review is bestowed on the current progress in the growth of α-AAs based PEAs and functionalized PEAs, the major polymerized routes utilized in their production along with their vital biomedical applications.