Photoactivatable CaMKII: Rewiring the Brain, One Synapse at a Time. Issue 4 (April 2021)

• Record Type: Journal Article
• Authors: Gee, Christine E.; Oertner, Thomas G.
• Is Part Of: Trends in neurosciences. Volume 44:Issue 4(2021)
• Page Start: 246
• Page End: 247
• Publication Date: 2021-04
• Subjects: CaMKII -- optogenetics -- LTP -- dendritic spine -- synaptic plasticity; Neurology -- Periodicals; Neurophysiology -- Periodicals; Neurobiology -- Periodicals; 612.8
• DOI: 10.1016/j.tins.2021.02.004
• Languages: English
• ISSNs: 0166-2236

Abstract

Abstract : A recent article by Shibata et al. introduces the engineered photoactivatable enzyme paCaMKII. Activation of this new tool is sufficient to induce long-term potentiation (LTP) of hippocampal synapses in slice culture and in intact animals, thereby expanding the existing toolkit for light-induced modification of brain connectivity at the synaptic level.