Morbidity and mortality of surgical lung biopsy in the diagnosis of usual interstitial pneumonia. Issue 3 (28th February 2021)

• Record Type: Journal Article
• Authors: Cilli, Aykut; Kocaturk, Celalettin; Tertemiz, Kemal C.; Kalafat, Cem E.; Hanta, Ismail; Odemis, Ayse; Sevinc, Can; Dertsiz, Levent; Akanil Fener, Neslihan
• Is Part Of: ANZ journal of surgery. Volume 91:Issue 3(2021)
• Page Start: 298
• Page End: 303
• Publication Date: 2021-02-28
• Subjects: surgical lung -- usual interstitial pneumonia -- video‐assisted thoracoscopic surgery; Surgery -- Periodicals; 617.005
• DOI: 10.1111/ans.16681
• Languages: English
• ISSNs: 1445-1433

Abstract

Abstract: Background: Histology represents the major source of information to define a usual interstitial pneumonia (UIP) pattern. However, the procedure is associated with significant morbidity and mortality. The aim of this study was to evaluate morbidity and mortality of surgical lung biopsy (SLB) in diagnosing UIP. Methods: Patients undergoing SLB with the ultimate diagnosis of UIP were studied. Clinical data concerning medical history, histology, pulmonary functions, radiology, length of hospital stay (LOS), morbidity and mortality status were retrospectively recruited from four hospitals. Results: The study included consecutive 93 patients with a SLB diagnosis of UIP. Mean age was 61 ± 8 years, with one third of the patients were ≥65 years. In 58 cases (62.4%), the biopsy was performed by video‐assisted thoracoscopic surgery, in 35 (37.7%) by limited thoracotomy. Eighty patients (86%) had possible UIP, 12 (12.9%) had inconsistent with UIP and one (1.1%) had UIP pattern on high‐resolution computed tomography. The mean LOS was 5.47 ± 3.16 days. LOS was associated with smoking status ( P = 0.024), type of biopsy ( P = 0.00), 6‐min walk test ( P = 0.00) and number of biopsy ( P = 0.00). There was no in‐hospital and 30‐day mortality in our cohort, and 90‐day mortality rate was 1.1%. In seven patients (7.5%), we observed postoperative morbidities, predominantly prolonged air leakage (7.5% of all cases). Postoperative morbidity was only associated with the type of SLB. Patients with limited thoracotomy showed greater morbidity rates (17.1% versus 1.7%, P = 0.011). Conclusion: SLB is a relatively safe procedure in the diagnosis of UIP and can be performed in suitable patients with suspected UIP/idiopathic pulmonary fibrosis. Abstract : Patients undergoing surgical lung biopsy with the ultimate diagnosis of usual interstitial pneumonia (UIP) were studied. Clinical data concerning medical history, histology, pulmonary functions, radiology, length of hospital stay, morbidity and mortality status were retrospectively recruited from four hospitals. Surgical lung biopsy is a relatively safe procedure in the diagnosis of UIP and can be performed in suitable patients with suspected UIP/idiopathic pulmonary fibrosis.