Cover Feature: Cysteine‐Rich Peptides: Hyperstable Scaffolds for Protein Engineering (6/2021). (3rd March 2021)

• Record Type: Journal Article
• Authors: González‐Castro, Rafael; Gómez‐Lim, Miguel A.; Plisson, Fabien
• Is Part Of: Chembiochem. Volume 22:Number 6(2021)
• Page Start: 938
• Page End: 938
• Publication Date: 2021-03-03
• Subjects: cysteine-rich peptides -- metabolic stability -- molecular grafting -- protein engineering -- thermal stability; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1002/cbic.202100083
• Languages: English
• ISSNs: 1439-4227

Abstract

Abstract : Cysteine‐rich peptides are being used as stable scaffolds to produce bioactive grafted peptides with either a single epitope (first generation), two identical epitopes (second generation), or two distinct epitopes (third generation). The spatial grid is a metaphor for the tridimensional design one needs to consider when combining a scaffold with one or more epitopes. More information can be found in the minireview by F. Plisson et al. Picture by R. G.‐C.