The potential use of theranostic bacteria in cancer. Issue 6 (10th November 2020)

• Record Type: Journal Article
• Authors: Azizian, Khalil; Pustokhina, Inna; Ghanavati, Roya; Hamblin, Michael R.; Amini, Abolfazl; Kouhsari, Ebrahim
• Is Part Of: Journal of cellular physiology. Volume 236:Issue 6(2021)
• Page Start: 4184
• Page End: 4194
• Publication Date: 2020-11-10
• Subjects: cancer -- diagnostics -- theranostics bacteria -- therapeutics -- tumoricidal agents; Physiology -- Periodicals; Cell physiology -- Periodicals; 571.6
• DOI: 10.1002/jcp.30152
• Languages: English
• ISSNs: 0021-9541

Abstract

Abstract: Conventional chemotherapy approaches have not been fully successful in the treatment of cancer, due to limitations imposed by the pathophysiology of solid tumors, leading to nonspecific drug uptake by healthy cells, poor bioavailability, and toxicity. Thus, novel therapeutic modalities for more efficient cancer treatment are urgently required. Living bacteria can be used as a theranostic approach for the simultaneous diagnosis and therapy of tumors. Herein, we summarize the currently available literature focused on the advantages and challenges for the use of theranostic bacteria in cancer therapy.