Biomaterials Discovery: Discovery of a Novel Polymer for Xeno‐Free, Long‐Term Culture of Human Pluripotent Stem Cell Expansion (Adv. Healthcare Mater. 6/2021). Issue 6 (17th March 2021)

• Record Type: Journal Article
• Authors: Nasir, Aishah; Thorpe, Jordan; Burroughs, Laurence; Meurs, Joris; Pijuan‐Galito, Sara; Irvine, Derek J.; Alexander, Morgan R.; Denning, Chris
• Is Part Of: Advanced healthcare materials. Volume 10:Issue 6(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-03-17
• Subjects: Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.202170019
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract : In article number 2001448 by Morgan R. Alexander, Chris Denning, and co‐workers, a novel substrate for xeno‐free human pluripotent stem cell (hPSC) culture is discovered using a highthroughput multigenerational polymer microarray platform approach used to rapidly test over 600 polymers. This nanoscale phase separated blend of poly(tricyclodecane‐dimethanol diacrylate) and poly(butyl acrylate) (2:1 v/v) which supports hPSC expansion and differentiation after long‐term serial passage can be readily applied to common tissue culture plasticware.