Deoxytrichodermaerin, a harziane lactone from the marine algicolous fungus Trichoderma longibrachiatum A-WH-20-2. Issue 2 (17th January 2021)

• Record Type: Journal Article
• Authors: Zou, Ji-Xue; Song, Yin-Ping; Ji, Nai-Yun
• Is Part Of: Natural product research. Volume 35:Issue 2(2021)
• Page Start: 216
• Page End: 221
• Publication Date: 2021-01-17
• Subjects: Trichoderma -- diterpene -- harziane -- deoxytrichodermaerin; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2019.1622110
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Three metabolites deoxytrichodermaerin (a new harziane lactone), harzianol A and harzianone were obtained from Trichoderma longibrachiatum A-WH-20-2, an endophyte from marine red alga Laurencia okamurai . Their structures and relative configurations were unequivocally assigned by spectroscopic techniques, and the absolute configuration of deoxytrichodermaerin was established by analysis of the ECD curve aided by quantum chemical calculations. Deoxytrichodermaerin represents the second harziane lactone with an ester linkage between C-10 and C-11. Harzianol A occurs as a natural product of Trichoderma for the first time. Harzianone has been previously discovered from T. longibrachiatum cf-11. These isolates exhibited potent inhibition of some marine plankton species. Graphical Abstract: