Recent Advances in Biomaterial Scaffolds for Integrative Tumor Therapy and Bone Regeneration. Issue 3 (31st December 2020)

• Record Type: Journal Article
• Authors: Huang, Ziyan; Tian, Zhengfang; Zhu, Min; Wu, Chengtie; Zhu, Yufang
• Is Part Of: Advanced therapeutics. Volume 4:Issue 3(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-12-31
• Subjects: biomaterial scaffolds -- bone regeneration -- bone tumors -- therapy; Therapeutics -- Periodicals; Pharmaceutical technology -- Periodicals; Pharmacogenetics -- Periodicals; 615.5
• DOI: 10.1002/adtp.202000212
• Languages: English
• ISSNs: 2366-3987

Abstract

Abstract: Bone tumors bring great pain to patients, along with a high disability rate and high mortality. Several therapeutic strategies have been applied to treat bone tumors, such as chemotherapy, radiotherapy, and surgical resection. However, these strategies have intrinsic drawbacks, such as the serious side effects of chemotherapy or the necessary reconstructive surgery of surgical resection. To help develop more satisfactory bone tumor treatment strategies, biomaterial scaffolds have been proposed. Biomaterial scaffolds are often applied for repairing bone defects after surgical resection due to their biocompatibility, osteoinductivity, and osteoconductivity as well as excellent physicochemical properties. Simultaneously, the function of bone tumor therapy offers biomaterial scaffolds to eliminate residual tumor cells, thus avoiding tumor recurrence. This review summarizes recent advances in biomaterial scaffolds which are combined with chemotherapy or hyperthermia therapy for treating bone tumors and further bone regeneration. Moreover, the progress in synergistic therapy of bone tumors based on biomaterial scaffolds is also discussed. This review aims to inspire researchers to develop novel fabrication or functionalization strategies for constructing multifunctional biomaterial scaffolds with anti‐tumor properties. Abstract : To achieve more satisfactory bone tumor treatment outcomes, biomaterial scaffolds with tumor therapy have been designed and fabricated. This review summarizes recent advances in biomaterial scaffolds with chemotherapy, hyperthermia therapy, and/or synergistic therapy for treating the defect after bone tumor resection. Furthermore, current challenges and further prospects of biomaterial scaffolds for integrative tumor therapy and bone regeneration are discussed.