Cancer Immunotherapy: Reprogramming the Tumor Microenvironment through Second‐Near‐Infrared‐Window Photothermal Genome Editing of PD‐L1 Mediated by Supramolecular Gold Nanorods for Enhanced Cancer Immunotherapy (Adv. Mater. 12/2021). Issue 12 (23rd March 2021)

• Record Type: Journal Article
• Authors: Tang, Honglin; Xu, Xiaojie; Chen, Yuxuan; Xin, Huhu; Wan, Tao; Li, Bowen; Pan, Hongming; Li, Da; Ping, Yuan
• Is Part Of: Advanced materials. Volume 33:Issue 12(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-03-23
• Subjects: CRISPR/Cas9 -- gene delivery -- immune checkpoint blockade -- immunogenic cell death -- nanomedicine; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.202170086
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract : In article number 2006003, Yuan Ping and co‐workers, by means of photothermal transcription of CRISPR/Cas9 in the second near‐infrared window, demonstrate genome editing of PD‐L1 to be effective to reprogram the tumor microenvironment. The photothermal genome editing for the disruption of PD‐L1 mediated by supramolecular gold nanorods also simultaneously activates T cells to infiltrate and attack tumor cells in the deep tissues, which can substantially improve cancer immunotherapy.