Accelerated Bone Regeneration by MOF Modified Multifunctional Membranes through Enhancement of Osteogenic and Angiogenic Performance. Issue 6 (14th January 2021)

• Record Type: Journal Article
• Authors: Xue, Yiyuan; Zhu, Zhou; Zhang, Xin; Chen, Junyu; Yang, Xiao; Gao, Xiaomeng; Zhang, Shu; Luo, Feng; Wang, Jian; Zhao, Weifeng; Huang, Chao; Pei, Xibo; Wan, Qianbing
• Is Part Of: Advanced healthcare materials. Volume 10:Issue 6(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-01-14
• Subjects: angiogenesis -- guided bone regeneration -- metal–organic frameworks -- sustained release -- zeolitic imidazolate framework‐8; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.202001369
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract: Owing to the insufficient guidance of new bone formation in orthopedic and craniomaxillofacial surgery, construction of a guided bone regeneration membrane to support vascularized bone regeneration remains a challenge. Herein, an electrospun asymmetric double‐layer polycaprolactone/collagen (PCL/Col) membrane modified by metal–organic framework (MOF) crystals is developed. The optimization of the PCL/Col weight ratio (1:1 and 1:1.5) enables the composite membrane with a balanced tensile strength (only fell by 49.9% in wet conditions) and a controlled degradation rate (completely degraded at 12 weeks). The MOF crystals can provide a pH‐responsive release of Zn 2+ ions. In vitro experiments indicate that the barrier layer functions to prevent the infiltration of fibrous connective tissue. The MOF crystal layer functions to enhance osteogenesis and angiogenesis in vitro. Using a rat calvarial defect model, the MOF crystals exhibit a sign of osteoinductivity along with blood vessel formation after 8 weeks post‐surgery. Strikingly, when assessed in a chick chorioallantoic membrane model, the MOF modified membrane demonstrates a significant angiogenic response, which can be envisaged as its outstanding merits over the commercially Col membrane. Therefore, the MOF crystals represent an exciting biomaterial option, with neovascularization capacity for bone tissue engineering and regenerative medicine. Abstract : The metal–organic framework (MOF) crystal coating is shown to facilitate osteogenesis and angiogenesis in vitro and in vivo. Strikingly, the MOF modified membrane demonstrates a significant angiogenic response versus commercially collagen membrane. The current work offers valuable information for exploring the interface of MOFs and biology, and motivates the application of MOF crystals in bone tissue engineering.