1α, 25-dihydroxyvitamin D3 promotes early osteogenic differentiation of PDLSCs and a 12-year follow-up case of early-onset vitamin D deficiency periodontitis. Issue 208 (April 2021)

• Record Type: Journal Article
• Authors: Qi, Ganggang; Yu, Ke; Feng, Yuting; Zhang, Yanmin; Shao, Qin; Yu, Mengjia; Wang, Yang; Ren, Lingfei; Zhu, Danji; Yang, Guoli; Jiang, Zhiwei
• Is Part Of: Journal of steroid biochemistry and molecular biology. Issue 208(2021)
• Publication Date: 2021-04
• Subjects: 1, 25(OH)2VitD3 -- VitD receptor -- Periodontal ligament stem cells -- Osteogenic differentiation -- Early tooth loss; Steroid hormones -- Periodicals; Biochemistry -- Periodicals; Hormones -- Periodicals; Molecular Biology -- Periodicals; Hormones stéroïdes -- Périodiques; Steroid hormones; Periodicals; 572.579
• DOI: 10.1016/j.jsbmb.2020.105805
• Languages: English
• ISSNs: 0960-0760

Abstract

Highlights: A case of early-onset periodontitis with VitD deficiency and VitD receptor mutation was reported. Vitamin D could promote early osteogenic differentiation of periodontal ligament stem cells (PDLSCs). Vitamin D could inhibit TNF-α-induced inflammation of PDLSCs. Abstract: Periodontitis is a chronic periodontal disease that contributes to tooth loss. In recent years, many animal studies have reported that vitamin D (VitD) deficiency results in chronic periodontitis. However, no studies have reported cases of early-onset periodontitis with VitD deficiency. This study reports a 5-year-old male patient with early-onset periodontitis, VitD deficiency and VitD receptor (VDR) mutation. The patient was treated with VitD and calcium, and received systematic periodontal treatment. During the 12-year treatment, the periodontal conditions of this patient were stable. Our in vitro study found that VitD could promote the expression of alkaline phosphatase (ALP), runt-related transcription factor 2 (Runx2), bone morphogenetic protein 2 (BMP2), bone gamma-carboxyglutamate protein (BGLAP), and VDR in the early osteogenic differentiation of periodontal ligament stem cells (PDLSCs). Meanwhile, VitD could downregulate mRNA expression levels of Interleukin-6 (IL-6), Interleukin-8 (IL-8), Interleukin-1β (IL-1β) and protein levels of IL-6 in the tumor necrosis factor-α (TNF-α) -induced inflammation of PDLSCs. Therefore, sufficient VitD supply can be a potential treatment for VitD deficiency induced early-onset periodontitis.