Xanthanoltrimer A–C: three xanthanolide sesquiterpene trimers from the fruits of Xanthium italicum Moretti isolated by HPLC-MS-SPE-NMR. Issue 6 (2nd February 2021)

• Record Type: Journal Article
• Authors: Fu, Jiang; Wang, Ya-Nan; Ma, Shuang-Gang; Li, Li; Wang, Xiao-Jing; Li, Yong; Liu, Yun-Bao; Qu, Jing; Yu, Shi-Shan
• Is Part Of: Organic chemistry frontiers. Volume 8:Issue 6(2021)
• Page Start: 1288
• Page End: 1293
• Publication Date: 2021-02-02
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/d0qo01541e
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : Xanthanoltrimer A–C, first three xanthanolide sesquiterpene trimers from the fruits of Xanthium italicum Moretti, were isolated by HPLC-MS-SPE-NMR. Xanthanoltrimer A–C had an unprecedented 5/7/6/5/7/6/5/7 polycyclic scaffold. Abstract : Xanthanoltrimer A–C (1–3 ), three xanthanolide sesquiterpene trimers, were first isolated from the fruits of Xanthium italicum Moretti by high-performance liquid chromatography-mass spectrometry-solid phase extraction-nuclear magnetic resonance spectroscopy (HPLC-MS-SPE-NMR). The structures of 1–3 were characterized by a series of spectroscopic methods, NMR calculations and electronic circular dichroism (ECD). Moreover, the cytotoxic, antiviral, anti-inflammatory, and antioxidant activities of 1–3 were screened, but they did not show significant biological activity.