A cerium oxide@metal–organic framework nanoenzyme as a tandem catalyst for enhanced photodynamic therapy. Issue 22 (19th February 2021)

• Record Type: Journal Article
• Authors: Liu, Jintong; Ye, Lin Yao; Xiong, Wei Hong; Liu, Tianrui; Yang, Hong; Lei, Jianping
• Is Part Of: Chemical communications. Volume 57:Issue 22(2021)
• Page Start: 2820
• Page End: 2823
• Publication Date: 2021-02-19
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d1cc00001b
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : An all-in-one CeO x @metal–organic framework hybrid has been developed for oxygen-promoted photodynamic therapy with self-feedback through tandem homogeneous catalysis. Abstract : An O2 self-evolving core–shell theranostic nanohybrid was developed by encapsulating a nanoenzyme cerium oxide (CeO x ) in a metal–organic framework (MOF). The hybrid reveals a 9-fold higher apoptotic percentage than bare CeO x in a harsh hypoxic microenvironment through tandem homogenous catalysis. Simultaneously, the oxygen-promoted therapeutic efficiency was self-monitored by the hybrid with caspase-3 activation, paving the way for MOF-functionalized nanoenzymes in theranostics.