CuO dot-decorated Cu@Gd2O3 core–shell hierarchical structure for Cu(i) self-supplying chemodynamic therapy in combination with MRI-guided photothermal synergistic therapy. Issue 3 (8th January 2021)

• Record Type: Journal Article
• Authors: Zhang, Guilong; Xie, Wenteng; Xu, Zhaowei; Si, Yuanchun; Li, Qingdong; Qi, Xiangyu; Gan, Yuehao; Wu, Zhengyan; Tian, Geng
• Is Part Of: Materials horizons. Volume 8:Issue 3(2021)
• Page Start: 1017
• Page End: 1028
• Publication Date: 2021-01-08
• Subjects: Materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/d0mh01685c
• Languages: English
• ISSNs: 2051-6347

Abstract

Abstract : Cu(i ) self-supplying core–shell nanoplatform is developed with enhanced Fenton-type catalytic activity for accelerating chemodynamic therapy in combination with MRI-guided photothermal synergistic therapy. Abstract : Theoretically, the Fenton catalytic efficiency of the Cu-based nanoplatform is approximately 160 times that of traditional Fe-based agents. However, the coordination interaction between Cu(ii ) and intracellular GSH significantly inhibits the high catalytic activity of Cu(i ) generation, dramatically decreasing the Fenton-like catalytic efficiency. Herein, we designed a completely new and highly efficient hierarchical structural nanoplatform to enhance the mimic-peroxidase activity through utilizing comproportionation between CuO and elemental Cu core to self-supply Cu(i ). The catalytic rate of this nanoplatform was approximately 55-fold that of traditional Fe-based agents. In a cell assay, this nanoplatform could function as an antagonist of GPX4 and agonist of SOD-1, resulting in intracellular ROS and H2 O2 accumulation. Next, the accumulated H2 O2 could be quickly catalyzed to highly toxic ˙OH by self-supplying Cu(i ), causing strong oxidative stress damage to mitochondria and cell membranes. Under 808 nm laser irradiation, this nanoplatform exhibited a stronger inhibition of tumor growth, and effectively overcame the tumor resistance and recurrence. In addition, this hierarchical structure significantly promoted the interaction between water molecules and gadolinium centers, making TRF-mCuGd possess an ultrahigh T 1 MRI contrast performance, and hence, more pathological information of the tumor could be achieved. Overall, this work provides a promising pattern for the design and development of cancer theranostics.