A cannabidiol-loaded Mg-gallate metal–organic framework-based potential therapeutic for glioblastomas. Issue 10 (3rd March 2021)

• Record Type: Journal Article
• Authors: Sharma, Anu; Kumar, Abhishek; Li, Changning; Panwar Hazari, Puja; Mahajan, Supriya D.; Aalinkeel, Ravikumar; Sharma, Rakesh Kumar; Swihart, Mark T.
• Is Part Of: Journal of materials chemistry. Volume 9:Issue 10(2021)
• Page Start: 2505
• Page End: 2514
• Publication Date: 2021-03-03
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/d0tb02780d
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : Anticancer effects of cannabidiol-loaded magnesium-gallate metal–organic framework were studied in a rat glioma cell line, revealing anti-inflammatory responses and triggering of apoptosis, suggesting promise for glioblastoma therapy. Abstract : Cannabidiol (CBD) has been shown to slow cancer cell growth and is toxic to human glioblastoma cell lines. Thus, CBD could be an effective therapeutic for glioblastoma. In the present study, we explored the anticancer effect of cannabidiol loaded magnesium-gallate (CBD/Mg-GA ) metal–organic framework (MOF) using the rat glioma brain cancer (C6) cell line. Bioactive and microporous magnesium gallate MOF was employed for simultaneous delivery of two potential anticancer agents (gallic acid and CBD) to the cancer cells. Gallic acid (GA), a polyphenolic compound, is part of the MOF framework, while CBD is loaded within the framework. Slow degradation of CBD/Mg-GA MOF in physiological fluids leads to sustained release of GA and CBD. CBD's anti-cancer actions target mitochondria, inducing their dysfunction and generation of harmful reactive oxygen species (ROS). Anticancer effects of CBD/Mg-GA include a significant increase in ROS production and a reduction in anti-inflammatory responses as reflected by a significant decrease in TNF-α expression levels. Molecular mechanisms that underlie these effects include the modulation of NF-κB expression, triggering the apoptotic cascades of glioma cells. CBD/Mg-GA MOF has potential anti-cancer, anti-inflammatory and anti-oxidant properties. Thus, the present study demonstrates that CBD/Mg-GA MOF may be a promising therapeutic for glioblastoma.