Recent advances in hydride transfer-involved C(sp3)–H activation reactions. Issue 6 (22nd January 2021)

• Record Type: Journal Article
• Authors: An, Xiao-De; Xiao, Jian
• Is Part Of: Organic chemistry frontiers. Volume 8:Issue 6(2021)
• Page Start: 1364
• Page End: 1383
• Publication Date: 2021-01-22
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/d0qo01502d
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : This review summarizes the recent progresses (2016–2020) in the hydride transfer-enabled C(sp 3 )–H activation according to the reaction types, categorized into the intramolecular/intermolecular C(sp 3 )–H functionalization, and hydride reduction. Abstract : The hydride transfer reaction, which is characterized by a redox-neutral and step/atom economic process, has emerged as an enabling platform for C(sp 3 )–H activation with high efficiency. During the past five years, significant advances have been made in new versions of hydride transfer-enabled C(sp 3 )–H activation, which mainly include the construction of novel scaffolds for cycles, and the intermolecular methods of both hydride transfer and C(sp 3 )–H functionalization. Herein, we summarize recent progress according to the reaction types categorized into hydride transfer/intramolecular C(sp 3 )–H functionalization, hydride transfer/intermolecular C(sp 3 )–H functionalization, and hydride reduction reactions. Furthermore, unsolved scientific problems as well as future directions in this field are also directly indicated. This review covers the period from 2016 to 2020.