Extracellular Vesicles during TriTryps infection: Complexity and future challenges. (April 2021)

• Record Type: Journal Article
• Authors: Rossi, Izadora Volpato; Ferreira Nunes, Maria Alice; Vargas-Otalora, Sandra; da Silva Ferreira, Thalita Camelo; Cortez, Mauro; Ramirez, Marcel Ivan
• Is Part Of: Molecular immunology. Volume 132(2021)
• Page Start: 172
• Page End: 183
• Publication Date: 2021-04
• Subjects: Cell communication -- Extracellular vesicles -- Host-parasite interaction -- Innate immunity -- TriTryps -- Trypanosomatids; Immunochemistry -- Periodicals; Molecular biology -- Periodicals; Immunochemistry -- Periodicals; Allergy and Immunology -- Periodicals; Molecular Biology -- Periodicals; Immunochimie -- Périodiques; Biologie moléculaire -- Périodiques; Immunochemistry; Molecular biology; Periodicals; Electronic journals; 571.96
• DOI: 10.1016/j.molimm.2021.01.008
• Languages: English
• ISSNs: 0161-5890

Abstract

Highlights: TriTryps EVs are complex due to the parasites' interfaces with host cells. TriTryps EVs surpass the innate immune attack, impacting the course of the disease. TriTryps EVs complexity is a challenge for the understanding of their functions. Abstract: The trypanosomatid pathogens Leishmania spp., Trypanosoma cruzi, and Trypanosoma brucei, currently grouped as TriTryps, have evolved through the time to overcome the upfront innate immune response and establish the infection in humans adapting many aspects of the parasite-cell host interaction. Extracellular vesicles (EVs) emerge as critical structures carrying different key molecules from parasites and target cells that interact continuously during infection. Current information regarding the structure and composition of these vesicles provide new insights into the primary role of TriTryps-EVs reviewed in this work. Expanding knowledge about these critical vesicular structures will promote advances in basic sciences and in translational applications controlling pathogenesis in the neglected tropical diseases caused by TriTryps.