Rate of radiation-induced microbleed formation on 7T MRI relates to cognitive impairment in young patients treated with radiation therapy for a brain tumor. (January 2021)

• Record Type: Journal Article
• Authors: Morrison, Melanie A.; Mueller, Sabine; Felton, Erin; Jakary, Angela; Stoller, Schuyler; Avadiappan, Sivakami; Yuan, Justin; Molinaro, Annette M.; Braunstein, Steve; Banerjee, Anu; Hess, Christopher P.; Lupo, Janine M.
• Is Part Of: Radiotherapy and oncology. Volume 154(2021)
• Page Start: 145
• Page End: 153
• Publication Date: 2021-01
• Subjects: CMBs cerebral microbleeds -- RT radiation therapy -- WBRT whole-brain RT -- WVRT whole-ventricular RT -- SWI susceptibility-weighted imaging; Cerebral microbleeds -- Radiation therapy -- Brain tumors -- Ultra-high field magnetic resonance imaging -- Cognitive outcome; Oncology -- Periodicals; Radiotherapy -- Periodicals; Tumors -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- radiotherapy -- Periodicals; Radiotherapy -- Periodicals; Radiothérapie -- Périodiques; Cancérologie -- Périodiques; Tumeurs -- Périodiques; Electronic journals; 616.9940642
• DOI: 10.1016/j.radonc.2020.09.028
• Languages: English
• ISSNs: 0167-8140

Abstract

Highlights: CMB detection sensitivity with 7T SWI was higher than reported at 1.5T and 3 T. 7T SWI revealed CMBs in 100% of patients treated with RT ≥1 year prior. Memory performance was most affected after RT. The rate of CMB development over time correlated with the rate of memory decline. Age, dose, time and brain volume exposed to RT influenced outcome. Abstract: Background: Radiation therapy (RT) is essential to the management of many brain tumors, but has been known to lead to cognitive decline and vascular injury in the form of cerebral microbleeds (CMBs). Purpose: In a subset of children, adolescents, and young adults recruited from a larger trial investigating arteriopathy and stroke risk after RT, we evaluated the prevalence of CMBs after RT, examined risk factors for CMBs and cognitive impairment, and related their longitudinal development to cognitive performance changes. Methods: Twenty-five patients (mean 17 years, range: 10–25 years) underwent 7-Tesla MRI and cognitive assessment. Nineteen patients were treated with whole-brain or focal RT 1-month to 20-years prior, while 6 non-irradiated patients with posterior-fossa tumors served as controls. CMBs were detected on 7T susceptibility-weighted imaging (SWI) using semi-automated software, a first use in this population. Results: CMB detection sensitivity with 7T SWI was higher than previously reported at lower field strengths, with one or more CMBs detected in 100% of patients treated with RT at least 1-year prior. CMBs were localized to dose-targeted brain volumes with risk factors including whole-brain RT ( p = 0.05), a higher RT dose ( p = 0.01), increasing time since RT ( p = 0.03), and younger age during RT ( p = 0.01). Apart from RT dose, these factors were associated with impaired memory performance. Follow-up data in a subset of patients revealed a proportional increase in CMB count with worsening verbal memory performance ( r = −0.85, p = 0.03). Conclusions: Treatment with RT during youth is associated with the chronic development of CMBs that evolve with memory impairment over time.