Cu-catalyzed cross-coupling of methyl ketones and pyridin-2-amines for the synthesis of N-(2-pyridyl)-α-ketoamides. Issue 5 (May 2021)

• Record Type: Journal Article
• Authors: Chen, Ali; Yang, Daji; Yu, Yue; Liu, Xiang; Rao, Chuixiong; Lin, Haoming; Guo, Pengfeng
• Is Part Of: Journal of chemical research. Volume 45:Issue 5/6(2021)
• Page Start: 417
• Page End: 421
• Publication Date: 2021-05
• Subjects: cross-coupling -- Cu-catalyzed -- methyl ketones -- pyridin-2-amines -- α-ketoamides; Chemistry -- Research -- Periodicals; Chemistry -- Periodicals; 540.5
• DOI: 10.1177/1747519820950222
• Languages: English
• ISSNs: 1747-5198

Abstract

An efficient copper-catalyzed strategy for the synthesis of α-ketoamides via cross-coupling of methyl ketones and pyridin-2-amines is described. This transformation has provided a simple process for the formation of C−N and C=O bonds to prepare α-ketoamides, which are important substrates and intermediates for the preparation of fine chemicals. The reaction mechanism is investigated, which suggests that the reaction proceeds via a radical pathway.