Maternal multiple sclerosis is not a risk factor for neurodevelopmental disorders in offspring. Issue 2 (May 2021)

• Record Type: Journal Article
• Authors: Carta, Alessandra; Zarbo, Ignazio R; Scoppola, Chiara; Pisuttu, Giulia; Conti, Marta; Melis, Maria C; Martino, Federica De; Serra, Antonella; Biancu, Maria A; Guerini, Franca R; Bazzardi, Riccardo; Sotgiu, Stefano
• Is Part Of: Multiple sclerosis journal, experimental, translational and clinical. Volume 7:Issue 2(2021)
• Publication Date: 2021-05
• Subjects: Neurodevelopmental disorders -- multiple sclerosis -- autism spectrum disorder -- attention deficit hyperactivity/impulsivity disorder -- specific learning disorders; Multiple sclerosis -- Periodicals; 616.834
• DOI: 10.1177/20552173211017301
• Languages: English
• ISSNs: 2055-2173

Abstract

Background: Childhood neurodevelopmental disorders (NDDs), including specific learning disorders (SLD), attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD), are pathogenically linked to familial autoimmunity and maternal immune-mediated diseases during pregnancy. Objective: We studied maternal MS as a potential risk factor for NDDs occurrence in offspring. Methods: MS and control mothers were subjected to questionnaires to ascertain NDD diagnosis in their progeny and the occurrence of both autoimmune and neurodevelopment disorders in their families. Suspected NDD cases were evaluated to confirm or rule out the diagnosis. Results: Of the 322 MS women, 206 (64%) have 361 children; of these, 27 (7.5%) were diagnosed with NDD (11% ADHD; 22% ASD; 67% SLD). NDD-risk in offspring was associated to family history of autoimmunity and to NDDs both in MS and non-MS mother families ( r = 0.75; p = 0.005) whereas it was not associated to maternal MS. Conclusions: For the first time, we demonstrate that maternal MS does not predispose children to higher risk for NDD. On a mechanistic view, we suggest that the intrinsic organ-specific nature of MS does not impair the mother–child cross-talk in decidua nor does it influence fetal neurodevelopment.