Challenges in antimalarial drug discovery. (September 2011)

• Record Type: Journal Article
• Authors: Burrows, Jeremy N; Leroy, Didier; Lotharius, Julie; Waterson, David
• Is Part Of: Future medicinal chemistry. Volume 3:Number 11(2011)
• Page Start: 1401
• Page End: 1412
• Publication Date: 2011-09
• Subjects: Pharmaceutical chemistry -- Periodicals; 615.19005
• DOI: 10.4155/fmc.11.91
• Languages: English
• ISSNs: 1756-8919

Abstract

Malaria is one of the most devastating diseases in the world, affecting almost 225 million people a year, and causing over 780, 000 deaths, most of which are children under the age of 5 years. Following the recent call for the eradication of the disease, supported by the WHO, there has been increasing investment into antimalarial drug-discovery projects. These activities are aimed at generating the next generation of molecules focused on the treatment and transmission-blocking of Plasmodium falciparum and Plasmodium vivax endo- and exo-erythrocytic stages of the parasite. This article summarizes the current top-level thinking regarding the prosecution of such endeavors and the disease-specific considerations in project planning.