Novel cosuspension metered-dose inhalers for the combination therapy of chronic obstructive pulmonary disease and asthma. (October 2011)

• Record Type: Journal Article
• Authors: Lechuga-Ballesteros, David; Noga, Brian; Vehring, Reinhard; Cummings, R Harris; Dwivedi, Sarvajna K
• Is Part Of: Future medicinal chemistry. Volume 3:Number 13(2011)
• Page Start: 1703
• Page End: 1718
• Publication Date: 2011-10
• Subjects: Pharmaceutical chemistry -- Periodicals; 615.19005
• DOI: 10.4155/fmc.11.133
• Languages: English
• ISSNs: 1756-8919

Abstract

Pressurized metered dose inhaler is the most common inhaled dosage form, ideally suited for delivering the highly potent compounds that medicinal chemists typically discover for respiratory therapeutic targets. The clinical benefit of combination therapy for asthma and chronic obstructive pulmonary disease has been well established, and many of the new discovery candidates are likely to be studied in the clinic as combination drugs even at early stages of development. We present a novel pressurized metered dose inhaler formulation approach to enable consistent aerosol performance of a respiratory therapeutic whether it is emitted from a single-, double- or triple-therapy product. This should enable rapid nonclinical and clinical assessment whether alone or in combination with other drugs, without the challenge of in vitro performance dissimilarity across product types.