Efficient synthesis of cucurbiturils and their derivatives using mechanochemical high-speed ball milling (HSBM). (June 2021)

• Record Type: Journal Article
• Authors: Xu, Wenhao; Li, Chengyu
• Is Part Of: High performance polymers. Volume 33:Number 5(2021)
• Page Start: 509
• Page End: 518
• Publication Date: 2021-06
• Subjects: Cucurbiturils -- ball milling -- green synthesis -- acid-free -- substituted cucurbiturils; Polymerization -- Periodicals; Polymers -- Periodicals; 547.7
• DOI: 10.1177/0954008320967057
• Languages: English
• ISSNs: 0954-0083

Abstract

Under solid-phase conditions, mechanical ball milling can be used to selectively prepare cucurbit[6]uril (CB[6]) and its derivatives without the use of catalysts and solvents. Using response surface method to determine the optimal conditions for the synthesis of CB[6]. The yield of CB[6] and its derivatives is 75–95%, with a high selectivity of more than 95%. In the synthesis of CB[6] using this method, the amount of acid required is significantly less, no organic solvent is needed, and the preparation of the fully aryl-substituted CB[6] is possible, which is otherwise difficult to be synthesized directly using traditional methods. Mechanical ball milling, thus, is of great significance in the synthesis and research of new cucurbituril supramolecules. Process scale-up experiments show that the yield and selectivity of the various types of cucurbiturils is higher than 95%, because of which they find good industrial applications.