Abhorring the vacuum: use of Alzheimer''s disease medications in frontotemporal dementia. (May 2011)

• Record Type: Journal Article
• Authors: Kerchner, Geoffrey A; Tartaglia, Maria Carmela; Boxer, Adam L
• Is Part Of: Expert review of neurotherapeutics. Volume 11:Number 5(2011)
• Page Start: 709
• Page End: 717
• Publication Date: 2011-05
• Subjects: Alzheimer''s disease -- frontotemporal dementia -- frontotemporal lobar degeneration -- FUS -- progressive nonfluent aphasia -- semantic dementia -- Tau -- TDP-43; Neuropharmacology -- Periodicals; 615.7805
• DOI: 10.1586/ern.11.6
• Languages: English
• ISSNs: 1473-7175

Abstract

There is no dedicated therapy for frontotemporal dementia (FTD). In order to treat the often devastating behavioral disturbances that interfere with both normal social functioning and the ability of caregivers to provide needed support, off-label medication usage is frequent. In addition to antidepressant and antipsychotic medications, which afford some benefits, US FDA-approved treatments for Alzheimer''s disease are often used, including both cholinesterase inhibitors and memantine. Here, we review the various clinical manifestations of FTD, a general approach to treatment and the goals of any potential therapies. We review all of the existing literature on the use of cholinesterase inhibitors and memantine in FTD. While cholinesterase inhibitors do not currently have a place in FTD treatment, memantine may be helpful, although the results of two placebo-controlled trials with this agent are not yet available. Finally, we discuss our view that such approaches will probably become supplanted by rational, molecularly-based therapies currently in development.