Evaluation of diagnostic criteria and red flags of myelin oligodendrocyte glycoprotein encephalomyelitis in a clinical routine cohort. (13th October 2020)

• Record Type: Journal Article
• Authors: Veselaj, Krenar; Kamber, Nicole; Briner, Myriam; Friedli, Christoph; Diem, Lara; Guse, Kirsten; Miclea, Andrei; Wiest, Roland; Wagner, Franca; Grabe, Hilary; Abegg, Mathias; Horn, Michael P.; Bigi, Sandra; Chan, Andrew; Hoepner, Robert; Salmen, Anke
• Is Part Of: CNS neuroscience & therapeutics. Volume 27:Number 4(2021)
• Page Start: 426
• Page End: 438
• Publication Date: 2020-10-13
• Subjects: cerebrospinal fluid -- multiple sclerosis -- myelin oligodendrocyte glycoprotein -- neuromyelitis optica spectrum disorders; Neuropharmacology -- Periodicals; Central nervous system -- Diseases -- Effect of drugs on -- Periodicals; 612.8
• DOI: 10.1111/cns.13461
• Languages: English
• ISSNs: 1755-5930

Abstract

Abstract: Aims: Myelin oligodendrocyte glycoprotein antibodies (MOG‐IgG) have been proposed to define "MOG encephalomyelitis" (MOG‐EM), with published diagnostic and "red flag" criteria. We aimed to evaluate these criteria in a routine clinical setting. Methods: We retrospectively analyzed patients with borderline/positive MOG‐IgG and applied the diagnostic and red flag criteria to determine likelihood of MOG‐EM diagnosis. Para‐/clinical parameters were described and analyzed with chi‐square test. Results: In total, 37 patients fulfilled MOG‐EM diagnostic criteria (female‐to‐male ratio: 1.6:1, median onset age: 28.0 years [IQR 18.5‐40.5], n = 8 with pediatric onset). In 24/37, red flags were present, predominantly MOG‐IgG at assay cutoff and/or MRI lesions suggestive of multiple sclerosis (MS). As proposed in the consensus criteria, these patients should rather be described as "possible" MOG‐EM. Of these, we classified 13 patients as "unlikely" MOG‐EM in the presence of the red flag "borderline MOG‐IgG" with negative MOG‐IgG retest or coincidence of ≥1 additional red flag. This group mainly consisted of patients diagnosed with MS (n = 11). Frequency of cerebrospinal fluid (CSF‐)—specific oligoclonal bands (OCB) is significantly lower in definite vs possible and unlikely MOG‐EM ( P = .0005). Conclusion: Evaluation of diagnostic and red flag criteria, MOG‐IgG retesting (incl. change of assay), and CSF‐specific OCB are relevant in clinical routine cohorts to differentiate MOG‐EM from MS. Abstract : Differential diagnosis of MOG encephalomyelitis vs. MS is crucial. Application of consensus diagnostic criteria and proposed red flags is helpful in a clinical routine cohort, and MOG‐IgG retesting (incl. change of assay) as well as evaluation of CSF‐specific OCB may further help in the distinction of the two entities.