PAKC: A novel panel of HLA class I antigen presentation machinery knockout cells from the same genetic origin. Issue 3 (1st February 2021)

• Record Type: Journal Article
• Authors: de Waard, Antonius A.; Verkerk, Tamara; Jongsma, Marlieke L. M.; Hoefakker, Kelly; Sethumadhavan, Sunesh; Gerke, Carolin; Bliss, Sophie; Kong, Xiangrui; Janssen, George M. C.; de Ru, Arnoud H.; Claas, Frans H. J.; Mulder, Arend; Tampé, Robert; van Veelen, Peter A.; Halenius, Anne; Spaapen, Robbert M.
• Is Part Of: European journal of immunology. Volume 51:Issue 3(2021)
• Page Start: 734
• Page End: 737
• Publication Date: 2021-02-01
• Subjects: APM -- antigen presentation -- HLA class I -- CRISPR/Cas9 -- MHC; Immunology -- Periodicals; 616.079
• DOI: 10.1002/eji.202048599
• Languages: English
• ISSNs: 0014-2980

Abstract

Abstract : A single model system for integrative studies on multiple facets of antigen presentation is lacking. PAKC is a novel panel of ten cell lines knocked out for individual components of the HLA class I antigen presentation pathway. PAKC will accelerate HLA‐I research in the fields of oncology, infectiology, and autoimmunity.