Programmed cell death in spinal cord injury pathogenesis and therapy. (27th January 2021)

• Record Type: Journal Article
• Authors: Shi, Zhongju; Yuan, Shiyang; Shi, Linlin; Li, Jiahe; Ning, Guangzhi; Kong, Xiaohong; Feng, Shiqing
• Is Part Of: Cell proliferation. Volume 54:Number 3(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-01-27
• Subjects: pathological mechanisms -- programmed cell death -- spinal cord injury -- therapy; Cell proliferation -- Periodicals; 571.84
• DOI: 10.1111/cpr.12992
• Languages: English
• ISSNs: 0960-7722

Abstract

Abstract: Spinal cord injury (SCI) always leads to functional deterioration due to a series of processes including cell death. In recent years, programmed cell death (PCD) is considered to be a critical process after SCI, and various forms of PCD were discovered in recent years, including apoptosis, necroptosis, autophagy, ferroptosis, pyroptosis and paraptosis. Unlike necrosis, PCD is known as an active cell death mediated by a cascade of gene expression events, and it is crucial for elimination unnecessary and damaged cells, as well as a defence mechanism. Therefore, it would be meaningful to characterize the roles of PCD to not only enhance our understanding of the pathophysiological processes, but also improve functional recovery after SCI. This review will summarize and explore the most recent advances on how apoptosis, necroptosis, autophagy, ferroptosis, pyroptosis and paraptosis are involved in SCI. This review can help us to understand the various functions of PCD in the pathological processes of SCI, and contribute to our novel understanding of SCI of unknown aetiology in the near future. Abstract : Different types of programmed cell death (PCD) play different roles in spinal cord injury. PCD is an active cell death mediated by a cascade of gene expression events, and it is crucial for elimination unnecessary and damaged cells, as well as a defense mechanism. PCD consists of a series of activities, such as apoptosis, necroptosis, autophagy, ferroptosis, pyroptosis and paraptosis. This figure indicates how how apoptosis, necroptosis, autophagy, ferroptosis, pyroptosis and paraptosis are involved in spinal cord injury.