Immunogenetics of xenotransplantation. (7th January 2021)

• Record Type: Journal Article
• Authors: Carvalho‐Oliveira, Marco; Valdivia, Emilio; Blasczyk, Rainer; Figueiredo, Constanca
• Is Part Of: International journal of immunogenetics. Volume 48:Number 2(2021)
• Page Start: 120
• Page End: 134
• Publication Date: 2021-01-07
• Subjects: gene therapy -- histocompatibility -- immunogenetics -- immunology -- organ bioengineering -- xenotransplantation; Immunogenetics -- Periodicals; 571.9648
• DOI: 10.1111/iji.12526
• Languages: English
• ISSNs: 1744-3121

Abstract

Abstract: Xenotransplantation may become the highly desired solution to close the gap between the availability of donated organs and number of patients on the waiting list. In recent years, enormous progress has been made in the development of genetically engineered donor pigs. The introduced genetic modifications showed to be efficient in prolonging xenograft survival. In this review, we focus on the type of immune responses that may target xeno‐organs after transplantation and promising immunogenetic modifications that show a beneficial effect in ameliorating or eliminating harmful xenogeneic immune responses. Increasing histocompatibility of xenografts by eliminating genetic discrepancies between species will pave their way into clinical application.