Anti-inflammatory monoterpene esters from the stems of Illigera aromatica. Issue 6 (19th March 2021)

• Record Type: Journal Article
• Authors: Pu, Xiao-Yun; Tian, Kai; Sun, Jing-Xian; Wang, Wei; Liu, Hong-Cheng; Yang, Juan; Jiang, Meng-Yuan; Huang, Xiang-Zhong
• Is Part Of: Natural product research. Volume 35:Issue 6(2021)
• Page Start: 960
• Page End: 966
• Publication Date: 2021-03-19
• Subjects: Monoterpene -- Illigera aromatica -- anti-inflammatory activity -- hernandiaceae; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2019.1614574
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Two new monoterpene esters illigerates F and G (1 and 2 ) together with 5 know compounds illigerate A (3 ), illigerate C (4 ), actinodaphnine (5 ), N-methylactinodaphnine(6 ) and N-methyllaurotetanine(7 ) were isolated from Illigera aromatica S. Z. Huang et S. L. Mo. Their structures were identified by extensive NMR data and by comparing with the known compounds. The anti-inflammatory activity of four monoterpenes (1 - 4 ) was evaluated by inhibiting nitric oxide (NO) production in lipopolysaccharide-activated murine macrophage RAW 264.7 cells and four monoterpenoids exhibited inhibitory effect with IC50 values of 71.5 ± 7.3, 74.7 ± 5.6, 48.0 ± 7.4 and 65.1 ± 3.7 μM, respectively. Graphical Abstract: