Enone-promoted decarboxylation of trans-4-hydroxy-l-proline in flow: a side-by-side comparison to batch. Issue 3 (7th January 2021)

• Record Type: Journal Article
• Authors: Pilkington, Rowan L.; Dallaston, Madeleine A.; Savage, G. Paul; Williams, Craig M.; Polyzos, Anastasios
• Is Part Of: Reaction chemistry & engineering. Volume 6:Issue 3(2021)
• Page Start: 486
• Page End: 493
• Publication Date: 2021-01-07
• Subjects: Reaction mechanisms (Chemistry) -- Periodicals; Chemical engineering -- Periodicals; Chemical engineering; Reaction mechanisms (Chemistry); Periodicals; 547.705
• DOI: 10.1039/d0re00442a
• Languages: English
• ISSNs: 2058-9883

Abstract

Abstract : An efficient and scalable enone-promoted method for the decarboxylation of trans -4-hydroxy-proline has been developed in flow to provide access to ( R )-pyrrolidin-3-ol hydrochloride using biomass-derived isophorone. Abstract : An efficient and scalable enone-promoted method for the decarboxylation of trans -4-hydroxy-proline has been developed in flow to provide access to ( R )-pyrrolidin-3-ol hydrochloride using biomass-derived isophorone. The advantages of deploying flow in this setting were reinforced by direct comparsion to batch. This method lays a foundation for fossil fuel and ammonia free alternative access to amines on scales relevant to manufacturing.